Neurodevelopmental outcomes after cardiac surgery in infancy.

ABSTRACT:

Background

Neurodevelopmental disability is the most common complication for survivors of surgery for congenital heart disease (CHD).

Methods

We analyzed individual participant data from studies of children evaluated with the Bayley Scales of Infant Development, second edition, after cardiac surgery between 1996 and 2009. The primary outcome was Psychomotor Development Index (PDI), and the secondary outcome was Mental Development Index (MDI).

Results

Among 1770 subjects from 22 institutions, assessed at age 14.5 ± 3.7 months, PDIs and MDIs (77.6 ± 18.8 and 88.2 ± 16.7, respectively) were lower than normative means (each P < .001). Later calendar year of birth was associated with an increased proportion of high-risk infants (complexity of CHD and prevalence of genetic/

SUBMITTER: Gaynor JW 

PROVIDER: S-EPMC4533222 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature