MiR-135 family members mediate podocyte injury through the activation of Wnt/β-catenin signaling.

ABSTRACT: The upregulation of Wnt/β-catenin signaling occurs in virtually all types of kidney disease and is associated with podocyte injury. However, the precise mechanisms involved in the development of kidney disease remain to be elucidated. MicroRNAs (miRNAs or miRs) are a class of short non-coding RNAs and they have been shown to be regulators of gene expression, mainly by binding to the untranslated region (UTR) of mRNAs. The aim of the present study was to determine the role of the 2 members of the miR-135 family (miR‑135a and miR‑135b) in podocyte injury and to elucidate the mechanisms responsible for the damage to podocytes. The results revealed that miR-135a and miR-135b were upregulated in models of podocyte injury and in glomeruli isolated from patients with focal segmental glomeruloscle

SUBMITTER: Yang X 

PROVIDER: S-EPMC4533775 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature