Adoptive immunotherapy for cancer or viruses.

ABSTRACT: Adoptive immunotherapy, or the infusion of lymphocytes, is a promising approach for the treatment of cancer and certain chronic viral infections. The application of the principles of synthetic biology to enhance T cell function has resulted in substantial increases in clinical efficacy. The primary challenge to the field is to identify tumor-specific targets to avoid off-tumor, on-target toxicity. Given recent advances in efficacy in numerous pilot trials, the next steps in clinical development will require multicenter trials to establish adoptive immunotherapy as a mainstream technology.

SUBMITTER: Maus MV 

PROVIDER: S-EPMC4533835 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature