Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study.

ABSTRACT:

Objective

To identify genetic variants that modify bladder cancer prognosis focusing on genes involved in major biological carcinogenesis processes (apoptosis, proliferation, DNA repair, hormone regulation, immune surveillance, and cellular metabolism), as nearly half of patients with bladder cancer experience recurrences reliable predictors of this recurrent phenotype are needed to guide surveillance and treatment.

Patients and methods

We analysed variant genotypes hypothesised to modify these processes in 563 patients with urothelial-cell carcinoma enrolled in a population-based study of incident bladder cancer conducted in New Hampshire, USA. After diagnosis, patients were followed over time to ascertain recurrence and survival status, making this one of the first populat

SUBMITTER: Andrew AS 

PROVIDER: S-EPMC4533837 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature