Targeting lysyl oxidase for molecular imaging in breast cancer.

ABSTRACT:

Introduction

Lysyl oxidase (LOX; ExPASy ENZYME entry: EC 1.4.3.13) and members of the LOX-like family, LOXL1-LOXL4, are copper-dependent enzymes that can modify proteins of the extracellular matrix. Expression of LOX is elevated in many human cancers, including breast cancer. LOX expression correlates with the level of tissue hypoxia, and it is known to play a critical role in breast cancer metastasis. The goal of the present study was to target LOX with (1) molecular probe fluorescent labeling to visualize LOX in vitro and (2) a radiolabeled peptide to target LOX in vivo in three different preclinical models of breast cancer.

Methods

Gene expression of all five members of the LOX family was analyzed at the transcript level via microarray analysis using tissue biopsy samples

SUBMITTER: Wuest M 

PROVIDER: S-EPMC4533939 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature