Safety of live attenuated influenza vaccine in atopic children with egg allergy.

ABSTRACT:

Background

Live attenuated influenza vaccine (LAIV) is an intranasal vaccine recently incorporated into the United Kingdom immunization schedule. However, it contains egg protein and, in the absence of safety data, is contraindicated in patients with egg allergy. Furthermore, North American guidelines recommend against its use in asthmatic children.

Objective

We sought to assess the safety of LAIV in children with egg allergy.

Methods

We performed a prospective, multicenter, open-label, phase IV intervention study involving 11 secondary/tertiary centers in the United Kingdom. Children with egg allergy (defined as a convincing clinical reaction to egg within the past 12 months and/or >95% likelihood of clinical egg allergy as per published criteria) were recruited. LAI

SUBMITTER: Turner PJ 

PROVIDER: S-EPMC4534767 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature