Pharmacogenetics as a tool to tailor antiretroviral therapy: A review.

ABSTRACT: Highly active antiretroviral therapy (HAART) has substantially changed human immunodeficiency virus (HIV) infection from an inexorably fatal condition into a chronic disease with a longer life expectancy. This means that HIV patients should receive antiretroviral drugs lifelong, and the problems concerning with a chronic treatment (tolerability, side effects, adherence to treatment) have now become dominant. In this context, strategies for the treatment personalization have taken a central role in optimizing the therapeutic response and prevention of adverse drug reactions. In this setting, the study of pharmacogenetics features could be a very useful tool in clinical practice; moreover, nowadays the study of genetic profiles allows optimizations in the therapeutic management of People Liv

SUBMITTER: Aceti A 

PROVIDER: S-EPMC4534812 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature