Association between δ-aminolevulinate dehydratase G177C polymorphism and blood lead levels in brain tumor patients.

ABSTRACT: As the δ-aminolevulinic acid dehydratase (ALAD) G177C polymorphism affects the toxicokinetics of lead in the body, and the corresponding exposure to lead may increase the risk of adult brain tumors, we hypothesize that there is a possible association of the ALAD G177C genotype and the risk of brain tumors in human. Therefore, the aim of the present study was to clarify the role of the ALAD enzyme gene polymorphism at position G177C in the pathogenesis of brain tumors and its correlation to lead exposure. The ALAD gene polymorphism at position G177C was genotyped using the polymerase chain reaction with restriction fragment length polymorphism method and measured the blood lead level by atomic absorption in 81 brain tumor patients and compared the results with 81 contro

SUBMITTER: Taha MM 

PROVIDER: S-EPMC4535054 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature