Dataset Information

Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.

ABSTRACT:

Background

New biomarkers are needed to identify the stage of hepatitis C virus (HCV)-infected diseases in order to reduce the mortality rates. Herein, we investigated whether serum 3β-hydroxysterol Δ24-reductase antibody (DHCR24 Ab) may serve as a prognostic marker for hepatitis C infection progression to hepatocellular carcinoma (HCC).

Methods

Serum DHCR24 Abs from 395 HCV-positive patients, including 133 chronic hepatitis (CHC), 85 liver cirrhosis (LCC), and 177 HCC (HCC-C) patients; 232 hepatitis B virus (HBV)-positive patients, including 103 chronic hepatitis (CHB), 56 liver cirrhosis (LCB), and 73 HCC (HCC-B) patients; and 24 healthy controls, were measured using enzyme-linked immunosorbent assay.

Results

The serum DHCR24 Ab levels were significantly higher in patients with CHC than in healthy controls, in LCC than in CHC, and in LCC than in HCC-C (P < 0.0001 for all). The concentration of serum DHCR24 Ab in HCC-B patients showed no significant difference compared to CHB and LCB patients (P = 0.1247). The DHCR24 Ab levels were significantly higher in early HCC-C than CHC or LCC patients and in late HCC-C compared to early HCC-C patients. The sensitivity of the DHCR24 Ab for HCC-C detection (70.6%) was higher than that of alpha-fetoprotein (AFP; 54.8%) and protein induced by vitamin K absence or antagonist-II (PIVKA-II; 42 · 5%). Moreover, DHCR24 was up-regulated in HCV-positive, but not HBV-positive tissues or HBV-negative, HCV-negative HCC specimens.

Conclusions

DHCR24 auto-antibody represents a potential noninvasive biomarker for HCV-related liver disease and may facilitate the diagnosis of PIVKA-II and AFP-negative HCC.

SUBMITTER: Ezzikouri S

PROVIDER: S-EPMC4535309 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.

Ezzikouri Sayeh S Kimura Kiminori K Sunagozaka Hajime H Kaneko Shuichi S Inoue Kazuaki K Nishimura Tomohiro T Hishima Tsunekazu T Kohara Michinori M Tsukiyama-Kohara Kyoko K

EBioMedicine 20150413 6

<h4>Background</h4>New biomarkers are needed to identify the stage of hepatitis C virus (HCV)-infected diseases in order to reduce the mortality rates. Herein, we investigated whether serum 3β-hydroxysterol Δ24-reductase antibody (DHCR24 Ab) may serve as a prognostic marker for hepatitis C infection progression to hepatocellular carcinoma (HCC).<h4>Methods</h4>Serum DHCR24 Abs from 395 HCV-positive patients, including 133 chronic hepatitis (CHC), 85 liver cirrhosis (LCC), and 177 HCC (HCC-C) pat ...[more]

PMID: 26288822

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Dataset Information

Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.

Background

Methods

Results

Conclusions

Publications

Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.

Similar Datasets

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