Ontology highlight
ABSTRACT:
SUBMITTER: Ganapathy U
PROVIDER: S-EPMC4535450 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Ganapathy Uday U Marrero Joeli J Calhoun Susannah S Eoh Hyungjin H de Carvalho Luiz Pedro Sorio LPS Rhee Kyu K Ehrt Sabine S
Nature communications 20150810
The human pathogen Mycobacterium tuberculosis (Mtb) likely utilizes host fatty acids as a carbon source during infection. Gluconeogenesis is essential for the conversion of fatty acids into biomass. A rate-limiting step in gluconeogenesis is the conversion of fructose 1,6-bisphosphate to fructose 6-phosphate by a fructose bisphosphatase (FBPase). The Mtb genome contains only one annotated FBPase gene, glpX. Here we show that, unexpectedly, an Mtb mutant lacking GLPX grows on gluconeogenic carbon ...[more]