Epigenetic regulation of serotype expression antagonizes transcriptome dynamics in Paramecium tetraurelia.

ABSTRACT: Phenotypic variation of a single genotype is achieved by alterations in gene expression patterns. Regulation of such alterations depends on their time scale, where short-time adaptations differ from permanently established gene expression patterns maintained by epigenetic mechanisms. In the ciliate Paramecium, serotypes were described for an epigenetically controlled gene expression pattern of an individual multigene family. Paradoxically, individual serotypes can be triggered in Paramecium by alternating environments but are then stabilized by epigenetic mechanisms, thus raising the question to which extend their expression follows environmental stimuli. To characterize environmental adaptation in the context of epigenetically controlled serotype expression, we used RNA-seq to characteriz

SUBMITTER: Cheaib M 

PROVIDER: S-EPMC4535620 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature