Comparison of genomic DNA methylation pattern among septic and non-septic newborns - An epigenome wide association study.

ABSTRACT: DNA methylation is the current strategy in the field of biomarker discovery due to its prognostic efficiency. Its role in prognosis and early diagnosis has been recognized in various types of cancer. Sepsis still remains one of the major causes of neonatal mortality. Delay in diagnosis of sepsis leads to treatment difficulties and poor outcome. In this study, we have done an epigenome wide search to identify potential markers for prognosis of neonatal sepsis which may improve the treatment strategies. We analyzed the CpG methylation status in the epigenome of three septic and non-septic babies using Illumina Infinium HumanMethylation450K methylation microarray. The microarray data was analyzed with Illumina GenomeStudio v2011.1. After screening for biological and clinical significance, we

SUBMITTER: Dhas DB 

PROVIDER: S-EPMC4535661 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature