Gene expression profiling of mononuclear cells from patients with sepsis secondary to community-acquired pneumonia.

ABSTRACT: Mechanisms governing the inflammatory response during sepsis involve crosstalk between diverse signaling pathways, but current knowledge provides an incomplete picture of the syndrome. Microarray-based expression profiling is a powerful approach for the investigation of complex clinical conditions such as sepsis. In this study, we investigated whole-genome expression profiles in mononuclear cells from septic patients admitted in intensive care units with community-acquired pneumonia. Blood samples were collected at the time of sepsis diagnosis and seven days later since we aimed to evaluate the role of biological processes or genes possibly involved in patient recovery. Here we provide a detailed description of the study design, including clinical information, experimental methods and proc

SUBMITTER: Severino P 

PROVIDER: S-EPMC4535862 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature