MiRNA expression profiling of formalin-fixed paraffin-embedded (FFPE) hereditary breast tumors.

ABSTRACT: Hereditary breast cancer constitutes only 5-10% of all breast cancer cases and is characterized by strong family history of breast and/or other associated cancer types. Only ~ 25% of hereditary breast cancer cases carry a mutation in BRCA1 or BRCA2 gene, while mutations in other rare high and moderate-risk genes and common low penetrance variants may account for additional 20% of the cases. Thus the majority of cases are still unaccounted for and designated as BRCAX tumors. MicroRNAs are small non-coding RNAs that play important roles as regulators of gene expression and are deregulated in cancer. To characterize hereditary breast tumors based on their miRNA expression profiles we performed global microarray miRNA expression profiling on a retrospective cohort of 80 FFPE breast tissues, in

SUBMITTER: Tanic M 

PROVIDER: S-EPMC4535901 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature