Genome-wide profiling to analyze the effects of Ox-LDL induced THP-1 macrophage-derived foam cells on gene expression.

ABSTRACT: Atherosclerosis has a high incidence and is harmful to human health. An elevated level of oxidized low-density lipoprotein (Ox-LDL) is one of the major risk factors for atherosclerosis. During atherogenesis progression, circulating monocytes adhere to the intima and differentiate into macrophages. After differentiation, intimal macrophages intake Ox-LDL via scavenger receptors, thereby transforming into foam cells. Foam cell formation due to excessive accumulation of cholesterol by macrophages is a pathological hallmark of atherosclerosis. To gain a molecular understanding of the effect of Ox-LDL in atherosclerosis development, we conducted a genome-wide analysis of the Ox-LDL-induced macrophage transformation by microarray gene expression profiling. Here we describe in details the content

SUBMITTER: Hu YW 

PROVIDER: S-EPMC4535961 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature