Immunobiotic Lactobacillus administered post-exposure averts the lethal sequelae of respiratory virus infection.

ABSTRACT: We reported previously that priming of the respiratory tract with immunobiotic Lactobacillus prior to virus challenge protects mice against subsequent lethal infection with pneumonia virus of mice (PVM). We present here the results of gene microarray which document differential expression of proinflammatory mediators in response to PVM infection alone and those suppressed in response to Lactobacillus plantarum. We also demonstrate for the first time that intranasal inoculation with live or heat-inactivated L. plantarum or Lactobacillus reuteri promotes full survival from PVM infection when administered within 24h after virus challenge. Survival in response to L. plantarum administered after virus challenge is associated with suppression of proinflammatory cytokines, limited virus recovery,

SUBMITTER: Percopo CM 

PROVIDER: S-EPMC4536168 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature