Inter- and intra-individual variations in seasonal and daily stabilities of the human gut microbiota in Japanese.

ABSTRACT: Relationships between human gut microbiota, dietary habits, and health/diseases are the subject of epidemiological and clinical studies. However, the temporal stability and variability of the bacterial community in fecal samples remain unclear. In this study, middle-aged Japanese male and female volunteers (n = 5 each) without disease were recruited from the Sakura Diet Study. Fecal samples and lifestyle information were collected in every quarter and at each defecation for 7 continuous days. Next-generation sequencing of 16S rDNA and hierarchical clustering showed no time trend and intra-individual differences in both fecal sample sets. Significant inter-individual variations in seasonal and daily fecal sample sets were detected for 24 and 23 out of 39 selected dominant genera (>0.1% of t

SUBMITTER: Hisada T 

PROVIDER: S-EPMC4536265 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature