Ontology highlight
ABSTRACT:
SUBMITTER: Gheni G
PROVIDER: S-EPMC4536302 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Cell reports 20141016 2
Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. The effect of incretins on insulin secretion occurs only at elevated glucose concentrations and is mediated by cAMP signaling, but the mechanism linking glucose metabolism and cAMP action in insulin secretion is unknown. We show here, using a metabolomics-based approach, that cytosolic glutamate derived from the malate-aspartate shuttle upon g ...[more]