MiR-184 Regulates Pancreatic β-Cell Function According to Glucose Metabolism.

ABSTRACT: In response to fasting or hyperglycemia, the pancreatic β-cell alters its output of secreted insulin; however, the pathways governing this adaptive response are not entirely established. Although the precise role of microRNAs (miRNAs) is also unclear, a recurring theme emphasizes their function in cellular stress responses. We recently showed that miR-184, an abundant miRNA in the β-cell, regulates compensatory proliferation and secretion during insulin resistance. Consistent with previous studies showing miR-184 suppresses insulin release, expression of this miRNA was increased in islets after fasting, demonstrating an active role in the β-cell as glucose levels lower and the insulin demand ceases. Additionally, miR-184 was negatively regulated upon the administration of a sucrose-rich di

SUBMITTER: Tattikota SG 

PROVIDER: S-EPMC4536436 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature