C677T (RS1801133 ) MTHFR gene polymorphism frequency in a colombian population.

ABSTRACT:

Introduction

Abnormal levels of the enzyme methylenetetrahydrofolate reductase (MTHFR) are associated with an increased risk of both cardiovascular and cerebrovascular disease and higher concentrations of homocysteine. Abnormal levels are also related to birth defects, pregnancy complications, cancer and toxicity to methotrexate (MTX). Polymorphisms of MTHFR affect the activity of the enzyme. Genetic associations have been related to treatment efficacy.

Objective

To establish the frequency of the C> T polymorphism at nucleotide 677 of the MTHFR gene in a group of Colombian individuals.

Methods

Data from pharmacogenetic microarrays that include MTX sensibility-associated polymorphisms were retrospectively collected (Pathway Genomics(®)). The frequency of the C> T MTHFR

SUBMITTER: Romero-Sanchez C 

PROVIDER: S-EPMC4536819 | biostudies-literature | 2015 Apr-Jun

REPOSITORIES: biostudies-literature