Ontology highlight
ABSTRACT:
SUBMITTER: Zur R
PROVIDER: S-EPMC4536989 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Zur Rafal R Garcia-Ibanez Laura L Nunez-Buiza Angel A Aparicio Noelia N Liappas Georgios G Escós Alejandra A Risco Ana A Page Angustias A Saiz-Ladera Cristina C Alsina-Beauchamp Dayanira D Montans José J Paramio Jesús M JM Cuenda Ana A
Oncotarget 20150501 15
The contribution of chronic skin inflammation to the development of squamous cell carcinoma (SCC) is poorly understood. While the mitogen-activated protein kinase p38α regulates inflammatory responses and tumour development, little is known about the role of p38γ and p38δ in these processes. Here we show that combined p38γ and p38δ (p38γ/δ) deletion blocked skin tumour development in a chemically induced carcinogenesis model. p38γ/δ deletion reduced TPA-induced epidermal hyperproliferation and i ...[more]