Ontology highlight
ABSTRACT:
SUBMITTER: Dai W
PROVIDER: S-EPMC4537043 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Oncotarget 20150501 15
Cancer cells exhibit an altered metabolic phenotype known as the aerobic glycolysis. The expression of HK2 changes the metabolic phenotype of cells to support cancerous growth. In the present study, we investigated the inhibitory effect of resveratrol on HK2 expression and hepatocellular carcinoma (HCC) cell glycolysis. Aerobic glycolysis was observed in four HCC cell lines compared to the normal hepatic cells. Resveratrol sensitized aerobic glycolytic HCC cells to apoptosis, and this effect was ...[more]