High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: a randomized, controlled pilot trial.

ABSTRACT:

Objective

To determine the effects of high-dose vitamin D on insulin sensitivity in polycystic ovary syndrome (PCOS).

Design

Randomized, placebo-controlled trial.

Setting

Academic medical center.

Patient(s)

Twenty-eight women with PCOS.

Intervention(s)

Vitamin D3, 12,000 IU, or placebo daily for 12 weeks.

Main outcome measure(s)

The primary outcome was quantitative insulin sensitivity check index. Secondary outcomes included glucose and insulin levels during a 75-g oral glucose tolerance test and blood pressure.

Result(s)

Twenty-two women completed the study. Compared with placebo, vitamin D significantly increased 25-hydroxyvitamin D (mean [95% confidence interval] in vitamin D group 20.1 [15.7 to 24.5] ng/mL at baseline and 65.7 [52.3 to

SUBMITTER: Raja-Khan N 

PROVIDER: S-EPMC4537163 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature