Genome wide association study: searching for genes underlying body mass index in the Chinese.

ABSTRACT:

Objective

Obesity is becoming a worldwide health problem. The genome wide association (GWA) study particularly for body mass index (BMI) has not been successfully conducted in the Chinese. In order to identify novel genes for BMI variation in the Chinese, an initial GWA study and a follow up replication study were performed.

Methods

Affymetrix 500K SNPs were genotyped for initial GWA of 597 Northern Chinese. After quality control, 281,533 SNPs were included in the association analysis. Three SNPs were genotyped in a Southern Chinese replication sample containing 2 955 Chinese Han subjects. Association analyses were performed by Plink software.

Results

Eight SNPs were significantly associated with BMI variation after false discovery rate (FDR) correction (P=5.45×10⁻⁷-7

SUBMITTER: Yang F 

PROVIDER: S-EPMC4537185 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature