Association of Mucosal Organisms with Patterns of Inflammation in Chronic Rhinosinusitis.

ABSTRACT:

Background

Chronic rhinosinusitis is a multifactorial process disease in which bacterial infection or colonization may play an important role in the initiation or persistence of inflammatory response. The association between mucosal bacteria presence and inflammatory patterns has only been partially explored.

Objective

To demonstrate specific mucosal microorganisms possible association with inflammatory patterns.

Methods

We collected nasal polyps or sinus tissues from a clinical selection of six patient groups with defined sinus disease using tissue biomarkers. In the tissues, we detected bacteria using peptide nucleic acid fluorescence in situ hybridization (PNA-FISH).

Results

After reviewing a total of 115 samples (15-20 samples per group), the mucosal presen

SUBMITTER: Chalermwatanachai T 

PROVIDER: S-EPMC4537217 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature