Intraspecies Genomic Diversity and Long-Term Persistence of Bifidobacterium longum.

ABSTRACT: Members of genus Bifidobacterium are Gram-positive bacteria, representing a large part of the human infant microbiota and moderately common in adults. However, our knowledge about their diversity, intraspecific phylogeny and long-term persistence in humans is still limited. Bifidobacterium longum is generally considered to be the most common and prevalent species in the intestinal microbiota. In this work we studied whole genome sequences of 28 strains of B. longum, including 8 sequences described in this paper. Part of these strains were isolated from healthy children during a long observation period (up to 10 years between isolation from the same patient). The three known subspecies (longum, infantis and suis) could be clearly divided using sequence-based phylogenetic methods, gene conte

SUBMITTER: Chaplin AV 

PROVIDER: S-EPMC4537262 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature