Rac-GTPases Regulate Microtubule Stability and Axon Growth of Cortical GABAergic Interneurons.

ABSTRACT: Cortical interneurons are characterized by extraordinary functional and morphological diversity. Although tremendous progress has been made in uncovering molecular and cellular mechanisms implicated in interneuron generation and function, several questions still remain open. Rho-GTPases have been implicated as intracellular mediators of numerous developmental processes such as cytoskeleton organization, vesicle trafficking, transcription, cell cycle progression, and apoptosis. Specifically in cortical interneurons, we have recently shown a cell-autonomous and stage-specific requirement for Rac1 activity within proliferating interneuron precursors. Conditional ablation of Rac1 in the medial ganglionic eminence leads to a 50% reduction of GABAergic interneurons in the postnatal cortex. Here

SUBMITTER: Tivodar S 

PROVIDER: S-EPMC4537417 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature