Connectome and Maturation Profiles of the Developing Mouse Brain Using Diffusion Tensor Imaging.

ABSTRACT: This paper presents a comprehensive effort to establish a structural mouse connectome using diffusion tensor magnetic resonance imaging coupled with connectivity analysis tools. This work lays the foundation for imaging-based structural connectomics of the mouse brain, potentially facilitating a whole-brain network analysis to quantify brain changes in connectivity during development, as well as deviations from it related to genetic effects. A connectomic trajectory of maturation during postnatal ages 2-80 days is presented in the C57BL/6J mouse strain, using a whole-brain connectivity analysis, followed by investigations based on local and global network features. The global network measures of density, global efficiency, and modularity demonstrated a nonlinear relationship with age. The

SUBMITTER: Ingalhalikar M 

PROVIDER: S-EPMC4537430 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature