MicroRNA-663 regulates human vascular smooth muscle cell phenotypic switch and vascular neointimal formation.

ABSTRACT:

Rationale

Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis after angioplasty. MicroRNAs (miRNAs) have emerged as important regulators for VSMC function, and we recently identified miR-663 as critical for controlling human aortic smooth muscle cell proliferation.

Objective

To investigate whether miR-663 plays a role in human VSMC phenotypic switch and the development of neointima formation.

Methods and results

By using quantitative reverse-transcription polymerase chain reaction, we found that miR-663 was significantly downregulated in human aortic VSMCs on platelet-derived growth factor treatment, whereas expression was markedly increased during VSMC differentiation. Furthermore

SUBMITTER: Li P 

PROVIDER: S-EPMC4537615 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature