Cerebellar Premotor Output Neurons Collateralize to Innervate the Cerebellar Cortex.

ABSTRACT: Motor commands computed by the cerebellum are hypothesized to use corollary discharge, or copies of outgoing commands, to accelerate motor corrections. Identifying sources of corollary discharge, therefore, is critical for testing this hypothesis. Here we verified that the pathway from the cerebellar nuclei to the cerebellar cortex in mice includes collaterals of cerebellar premotor output neurons, mapped this collateral pathway, and identified its postsynaptic targets. Following bidirectional tracer injections into a distal target of the cerebellar nuclei, the ventrolateral thalamus, we observed retrogradely labeled somata in the cerebellar nuclei and mossy fiber terminals in the cerebellar granule layer, consistent with collateral branching. Corroborating these observations, bidirectiona

SUBMITTER: Houck BD 

PROVIDER: S-EPMC4537674 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature