Detecting gene-environment interactions in human birth defects: Study designs and statistical methods.

ABSTRACT:

Background

The National Birth Defects Prevention Study (NBDPS) contains a wealth of information on affected and unaffected family triads, and thus provides numerous opportunities to study gene-environment interactions (G×E) in the etiology of birth defect outcomes. Depending on the research objective, several analytic options exist to estimate G×E effects that use varying combinations of individuals drawn from available triads.

Methods

In this study, we discuss important considerations in the collection of genetic data and environmental exposures.

Results

We will also present several population- and family-based approaches that can be applied to data from the NBDPS including case-control, case-only, family-based trio, and maternal versus fetal effects. For each, we de

SUBMITTER: Tai CG 

PROVIDER: S-EPMC4537677 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature