Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Gyorgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics.

ABSTRACT: Impaired function of certain mitochondrial respiratory complexes has long been linked to the pathogenesis of chronic neurodegenerative disorders such as Parkinson's and Huntington's diseases. Furthermore, genetic alterations of mitochondrial genome or nuclear genes encoding proteins playing essential roles in maintaining proper mitochondrial function can lead to the development of severe systemic diseases associated with neurodegeneration and vacuolar myelinopathy. At present, all of these diseases lack effective disease modifying therapy. Following a brief commemoration of Professor Albert Szent-Györgyi, a Nobel Prize laureate who pioneered in the field of cellular respiration, antioxidant processes, and the roles of free radicals in health and disease, the present paper overviews the cur

SUBMITTER: Szalardy L 

PROVIDER: S-EPMC4537740 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature