Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.

ABSTRACT:

Purpose

Myxopapillary ependymoma (MPE) is a distinct histologic variant of ependymoma arising commonly in the spinal cord. Despite an overall favorable prognosis, distant metastases, subarachnoid dissemination, and late recurrences have been reported. Currently, the only effective treatment for MPE is gross-total resection. We characterized the genomic and transcriptional landscape of spinal ependymomas in an effort to delineate the genetic basis of this disease and identify new leads for therapy.

Experimental design

Gene expression profiling was performed on 35 spinal ependymomas, and copy number profiling was done on an overlapping cohort of 46 spinal ependymomas. Functional validation experiments were performed on tumor lysates consisting of assays measuring pyruvate kina

SUBMITTER: Mack SC 

PROVIDER: S-EPMC4537825 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature