Optical projection tomography permits efficient assessment of infarct volume in the murine heart postmyocardial infarction.

ABSTRACT: The extent of infarct injury is a key determinant of structural and functional remodeling following myocardial infarction (MI). Infarct volume in experimental models of MI can be determined accurately by in vivo magnetic resonance imaging (MRI), but this is costly and not widely available. Experimental studies therefore commonly assess injury by histological analysis of sections sampled from the infarcted heart, an approach that is labor intensive, can be subjective, and does not fully assess the extent of injury. The present study aimed to assess the suitability of optical projection tomography (OPT) for identification of injured myocardium and for accurate and efficient assessment of infarct volume. Intact, perfusion-fixed, optically cleared hearts, collected from mice 7 days after induc

SUBMITTER: Zhao X 

PROVIDER: S-EPMC4537945 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature