Association between TCF7L2 polymorphisms and breast cancer susceptibility: a meta-analysis.

ABSTRACT:

Aim

Our aim was to investigate the relationship between transcription factor 7-like 2 (TCF7L2) polymorphisms and breast cancer susceptibility.

Methods

PubMed, Embase and CNKI databases were used to search the related studies investigating the correlation between TCF7L2 polymorphisms and breast cancer susceptibility. Pooled ORs and 95% CIs, based on five genetic models, were applied to estimate the association betweenTCF7L2 polymorphisms and breast cancer. A fixed-effect model or a random-effect model was applied according to the between-study heterogeneity.

Results

We analyzed six single nucleotide polymorphisms (SNPs) in TCF7L2 gene, namely rs12255372, rs7903146, rs7900150, rs3750805, rs1225404 and rs7003146. The increased risk of breast cancer was associated with TC

SUBMITTER: Wang F 

PROVIDER: S-EPMC4537972 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature