KCNA5 gene polymorphism associate with idiopathic atrial fibrillation.

ABSTRACT:

Objective

To investigate the correlation between KCNA5 single nucleotide polymorphism (SNP) and idiopathic atrial fibrillation (IAF).

Methods

A case-control study was conducted, including 282 cases of IAF patients and 300 cases of age and sex-matched normal controls; gene sequencing method was used to detect the distribution of KCNA5 SNP (rs3741930 and rs1056468) in the two groups. The IAF patients were divided into two groups based on the different genotypes of rs1056468 and rs3741930; differences in clinical parameters between the two groups of patients were compared.

Results

For rs3741930, the CC, CT and TT genotype frequencies in the IAF group were 16.7%, 50.0%, and 33.3% respectively; C allele frequency in IAF group was 41.7%; in the normal control group, those w

SUBMITTER: Tian L 

PROVIDER: S-EPMC4538049 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature