Both PON1 Q192R and CYP2C19*2 influence platelet response to clopidogrel and ischemic events in Chinese patients undergoing percutaneous coronary intervention.

ABSTRACT: Clopidogrel nonresponsiveness increases the recurrence of cardiovascular events in patients undergoing percutaneous coronary intervention (PCI). Previous studies found that genetic variants such as single nucleotide polymorphisms (SNPs) of CYP2C19 and PON1 may influence clopidogrel response, cause high platelet reactivity (HPR) and increase cardiovascular events. However, these studies were inconsistent and inconclusive, especially in the Eastern Asian population. In this study, we investigated the effects of genetic variants on clopidogrel response and clinical outcomes in Chinese patients undergoing PCI. A total of 336 acute coronary syndrome patients undergoing PCI were included, 53 (15.77%) of whom were categorized as HPR. Among the 10 SNPs studied (ABCB1, CYP2C19*2, CYP2C19*3, CYP2C19

SUBMITTER: Chen Y 

PROVIDER: S-EPMC4538118 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature