Association of Vitamin D receptor gene TaqI polymorphisms with tuberculosis susceptibility: a meta-analysis.

ABSTRACT: Vitamin D receptor (VDR) is a receptor of vitamin D3, which plays a pivotal role in regulating cell proliferation and differentiation, lymphocyte activation and cytokine production, and is associated with TB susceptibility. Growing studies explored the association of TaqI polymorphism of VDR with tuberculosis (TB) susceptibility. However, the results were inconsistent and conflicting. To assess the relationship between the VDR TaqI gene polymorphism and the risk of TB, a meta-analysis was performed. Databases including PubMed and EMbase were systematically searched for genetic association studies of TaqI polymorphism of VDR and tuberculosis until February 15, 2015. Data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to

SUBMITTER: Cao Y 

PROVIDER: S-EPMC4538126 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature