Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis.

ABSTRACT: The ability of skeletal muscle to hypertrophy in response to a growth stimulus is known to be compromised in older individuals. We hypothesized that a change in the expression of protein-encoding genes in response to a hypertrophic stimulus contributes to the blunted hypertrophy observed with aging. To test this hypothesis, we determined gene expression by microarray analysis of plantaris muscle from 5- and 25-mo-old mice subjected to 1, 3, 5, 7, 10, and 14 days of synergist ablation to induce hypertrophy. Overall, 1,607 genes were identified as being differentially expressed across the time course between young and old groups; however, the difference in gene expression was modest, with cluster analysis showing a similar pattern of expression between the two groups. Despite ribosome protei

SUBMITTER: Kirby TJ 

PROVIDER: S-EPMC4538281 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature