Transcriptional Pathways in cPGI2-Induced Adipocyte Progenitor Activation for Browning.

ABSTRACT: De novo formation of beige/brite adipocytes from progenitor cells contributes to the thermogenic adaptation of adipose tissue and holds great potential for the therapeutic remodeling of fat as a treatment for obesity. Despite the recent identification of several factors regulating browning of white fat, there is a lack of physiological cell models for the mechanistic investigation of progenitor-mediated beige/brite differentiation. We have previously revealed prostacyclin (PGI2) as one of the few known endogenous extracellular mediators promoting de novo beige/brite formation by relaying β-adrenergic stimulation to the progenitor level. Here, we present a cell model based on murine primary progenitor cells defined by markers previously shown to be relevant for in vivo browning, including a

SUBMITTER: Bayindir I 

PROVIDER: S-EPMC4538297 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature