Immunosuppressive drugs affect high-mannose/hybrid N-glycans on human allostimulated leukocytes.

ABSTRACT: N-glycosylation plays an important role in the majority of physiological and pathological processes occurring in the immune system. Alteration of the type and abundance of glycans is an element of lymphocyte differentiation; it is also common in the development of immune-mediated inflammatory diseases. The N-glycosylation process is very sensitive to different environmental agents, among them the pharmacological environment of immunosuppressive drugs. Some results show that high-mannose oligosaccharides have the ability to suppress different stages of the immune response. We evaluated the effects of cyclosporin A (CsA) and rapamycin (Rapa) on high-mannose/hybrid-type glycosylation in human leukocytes activated in a two-way mixed leukocyte reaction (MLR). CsA significantly reduced the numbe

SUBMITTER: Pochec E 

PROVIDER: S-EPMC4538311 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature