Detecting Genetic Interactions for Quantitative Traits Using m-Spacing Entropy Measure.

ABSTRACT: A number of statistical methods for detecting gene-gene interactions have been developed in genetic association studies with binary traits. However, many phenotype measures are intrinsically quantitative and categorizing continuous traits may not always be straightforward and meaningful. Association of gene-gene interactions with an observed distribution of such phenotypes needs to be investigated directly without categorization. Information gain based on entropy measure has previously been successful in identifying genetic associations with binary traits. We extend the usefulness of this information gain by proposing a nonparametric evaluation method of conditional entropy of a quantitative phenotype associated with a given genotype. Hence, the information gain can be obtained for any phe

SUBMITTER: Yee J 

PROVIDER: S-EPMC4538333 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature