Imidazolium salts as small-molecule urinary bladder exfoliants in a murine model.

ABSTRACT: We present a novel family of small-molecule urinary bladder exfoliants that are expected to be of great value in preclinical studies of urologic conditions and have improved potential for translation compared with prior agents. There is broad urologic interest in the therapeutic potential of such exfoliating agents. The primary agent used in preclinical models, the cationic peptide protamine sulfate (PS), has limited translational potential due to concerns including systemic adverse reactions and bladder tissue injury. Intravesical application of a safe, systemically nontoxic exfoliant would have potential utility in the eradication of Escherichia coli and other uropathogens that reside in the bladder epithelium following cystitis, as well as in chronic bladder pain and bladder cancer. Her

SUBMITTER: Wagers PO 

PROVIDER: S-EPMC4538537 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature