Impact of image-based motion correction on dopamine D3/D2 receptor occupancy-comparison of groupwise and frame-by-frame registration approaches.

ABSTRACT:

Background

Image registration algorithms are frequently used to align the reconstructed brain PET frames to remove subject head motion. However, in occupancy studies, this is a challenging task where competitive binding of a drug can further reduce the available signal for registration. The purpose of this study is to evaluate two kinds of algorithms-a conventional frame-by-frame (FBF) registration and a recently introduced groupwise image registration (GIR), for motion correction of a dopamine D3/D2 receptor occupancy study.

Methods

The FBF method co-registers all the PET frames to a common reference based on normalised mutual information as the spatial similarity. The GIR method incorporates a pharmacokinetic model and conducts motion correction by maximising a likelihood

SUBMITTER: Jiao J 

PROVIDER: S-EPMC4538721 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature