Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization.

ABSTRACT: The controlled delivery of nucleic acids to selected tissues remains an inefficient process mired by low transfection efficacy, poor scalability because of varying efficiency with cell type and location, and questionable safety as a result of toxicity issues arising from the typical materials and procedures employed. High efficiency and minimal toxicity in vitro has been shown for intracellular delivery of nuclei acids by using nanoneedles, yet extending these characteristics to in vivo delivery has been difficult, as current interfacing strategies rely on complex equipment or active cell internalization through prolonged interfacing. Here, we show that a tunable array of biodegradable nanoneedles fabricated by metal-assisted chemical etching of silicon can access the cytosol to co-deliver

SUBMITTER: Chiappini C 

PROVIDER: S-EPMC4538992 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature