Genomic basis of aging and life-history evolution in Drosophila melanogaster.

ABSTRACT: Natural diversity in aging and other life-history patterns is a hallmark of organismal variation. Related species, populations, and individuals within populations show genetically based variation in life span and other aspects of age-related performance. Population differences are especially informative because these differences can be large relative to within-population variation and because they occur in organisms with otherwise similar genomes. We used experimental evolution to produce populations divergent for life span and late-age fertility and then used deep genome sequencing to detect sequence variants with nucleotide-level resolution. Several genes and genome regions showed strong signatures of selection, and the same regions were implicated in independent comparisons, suggesting

SUBMITTER: Remolina SC 

PROVIDER: S-EPMC4539122 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature