Targeting of chemoprevention to high-risk potentially malignant oral lesions: challenges and opportunities.

ABSTRACT: Worldwide, oral cancer is responsible for 170,000 deaths per year. Intervention to prevent this disease is a long sought after goal. Chemoprevention studies have focused on clinicopathological features of potentially malignant lesions (PML) in an effort to prevent their progression to cancer. However, prediction of future behavior for such lesions is difficult and remains a major challenge to such intervention. Different approaches to this problem have been tested in the past 20years. Early genetic progression models identified critical regions of allelic imbalance at 3p and 9p, and provided the basis for molecular markers to identify progressing PMLs. Subsequently, technological advances, such as genome-wide high-throughput array platforms, computer imaging, visualization technology and n

SUBMITTER: Martinez VD 

PROVIDER: S-EPMC4539364 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature