A Prospective Pilot Trial for Pallidal Deep Brain Stimulation in Huntington's Disease.

ABSTRACT:

Background

Movement disorders in Huntington's disease are often medically refractive. The aim of the trial was assessment of procedure safety of deep brain stimulation, equality of internal- and external-pallidal stimulation and efficacy followed-up for 6 months in a prospective pilot trial.

Methods

In a controlled double-blind phase six patients (four chorea-dominant, two Westphal-variant) with predominant movement disorder were randomly assigned to either the sequence of 6-week internal- or 6-week external-pallidal stimulation, or vice versa, followed by further 3 months chronic pallidal stimulation at the target with best effect-side-effect ratio. Primary endpoints were changes in the Unified Huntington's Disease Rating Scale motor-score, chorea subscore, and total motor-

SUBMITTER: Wojtecki L 

PROVIDER: S-EPMC4539552 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature