Functional Analysis and Characterization of Differential Coexpression Networks.

ABSTRACT: Differential coexpression analysis is emerging as a complement to conventional differential gene expression analysis. The identified differential coexpression links can be assembled into a differential coexpression network (DCEN) in response to environmental stresses or genetic changes. Differential coexpression analyses have been successfully used to identify condition-specific modules; however, the structural properties and biological significance of general DCENs have not been well investigated. Here, we analyzed two independent Saccharomyces cerevisiae DCENs constructed from large-scale time-course gene expression profiles in response to different situations. Topological analyses show that DCENs are tree-like networks possessing scale-free characteristics, but not small-world. Function

SUBMITTER: Hsu CL 

PROVIDER: S-EPMC4539605 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature