PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications.

ABSTRACT:

Background

Most biological processes are influenced by protein post-translational modifications (PTMs). Identifying novel PTM sites in different organisms, including humans and model organisms, has expedited our understanding of key signal transduction mechanisms. However, with increasing availability of deep, quantitative datasets in diverse species, there is a growing need for tools to facilitate cross-species comparison of PTM data. This is particularly important because functionally important modification sites are more likely to be evolutionarily conserved; yet cross-species comparison of PTMs is difficult since they often lie in structurally disordered protein domains. Current tools that address this can only map known PTMs between species based on known orthologous phosphosi

SUBMITTER: Chaudhuri R 

PROVIDER: S-EPMC4539857 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature